General Hip/Elbow Dysplasia Information

Also information on Pra eye disease


The Dysplastic Joint


Hip Dysplasia is a terrible genetic disease because of the various degrees of arthritis (also called degenerative joint disease, arthrosis, osteoarthrosis) it can eventually produce, leading to pain and debilitation.

The very first step in the development of arthritis is articular cartilage (the type of cartilage lining the joint) damage due to the inherited bad biomechanics of an abnormally developed hip joint. Traumatic articular fracture through the joint surface is another way cartilage is damaged. With cartilage damage, lots of degradative enzymes are released into the joint. These enzymes degrade and decrease the synthesis of important constituent molecules that form hyaline cartilage called proteoglycans. This causes the cartilage to lose its thickness and elasticity, which are important in absorbing mechanical loads placed across the joint during movement. Eventually, more debris and enzymes spill into the joint fluid and destroy molecules called glycosaminoglycan and hyaluronate which are important precursors that form the cartilage proteoglycans. The joint's lubrication and ability to block inflammatory cells are lost and the debris-tainted joint fluid loses its ability to properly nourish the cartilage through impairment of nutrient-waste exchange across the joint cartilage cells. The damage then spreads to the synovial membrane lining the joint capsule and more degradative enzymes and inflammatory cells stream into the joint. Full thickness loss of cartilage allows the synovial fluid to contact nerve endings in the subchondral bone, resulting in pain. In an attempt to stabilize the joint to decrease the pain, the animal's body produces new bone at the edges of the joint surface, joint capsule, ligament and muscle attachments (bone spurs). The joint capsule also eventually thickens and the joint's range of motion decreases.

No one can predict when or even if a dysplastic dog will start showing clinical signs of lameness due to pain. There are multiple environmental factors such as caloric intake, level of exercise, and weather that can affect the severity of clinical signs and phenotypic expression (radiographic changes). There is no rhyme or reason to the severity of radiographic changes correlated with the clinical findings. There are a number of dysplastic dogs with severe arthritis that run, jump, and play as if nothing is wrong and some dogs with barely any arthritic radiographic changes that are severely lame.

Hip Grades


The phenotypic evaluation of hips done by the Orthopedic Foundation for Animals falls into seven different categories. Those categories are normal (Excellent, Good, Fair), Borderline, and dysplastic (Mild, Moderate, Severe). Once each of the radiologists classifies the hip into one of the 7 phenotypes above, the final hip grade is decided by a consensus of the 3 independent outside evaluations. Examples would be:

  1. Two radiologists reported excellent, one good—the final grade would be excellent
  2. One radiologist reported excellent, one good, one fair—the final grade would be good
  3. One radiologist reported fair, two radiologists reported mild—the final grade would be mild

The hip grades of excellent, good and fair are within normal limits and are given OFA numbers. This information is accepted by AKC on dogs with permanent identification (tattoo, microchip) and is in the public domain. Radiographs of borderline, mild, moderate and severely dysplastic hip grades are reviewed by the OFA radiologist and a radiographic report is generated documenting the abnormal radiographic findings. Unless the owner has chosen the open database, dysplastic hip grades are not in the public domain.

Excellent


Excellent (Figure 1): this classification is assigned for superior conformation in comparison to other animals of the same age and breed. There is a deep seated ball (femoral head) which fits tightly into a well-formed socket (acetabulum) with minimal joint space. There is almost complete coverage of the socket over the ball.

Good


Good (Figure 2): slightly less than superior but a well-formed congruent hip joint is visualized. The ball fits well into the socket and good coverage is present.

Fair


Fair (Figure 3): Assigned where minor irregularities in the hip joint exist. The hip joint is wider than a good hip phenotype. This is due to the ball slightly slipping out of the socket causing a minor degree of joint incongruency. There may also be slight inward deviation of the weight-bearing surface of the socket (dorsal acetabular rim) causing the socket to appear slightly shallow (Figure 4). This can be a normal finding in some breeds however, such as the Chinese Shar Pei, Chow Chow, and Poodle.

Borderline


Borderline: there is no clear cut consensus between the radiologists to place the hip into a given category of normal or dysplastic. There is usually more incongruency present than what occurs in the minor amount found in a fair but there are no arthritic changes present that definitively diagnose the hip joint being dysplastic. There also may be a bony projection present on any of the areas of the hip anatomy illustrated above that can not accurately be assessed as being an abnormal arthritic change or as a normal anatomic variant for that individual dog. To increase the accuracy of a correct diagnosis, it is recommended to repeat the radiographs at a later date (usually 6 months). This allows the radiologist to compare the initial film with the most recent film over a given time period and assess for progressive arthritic changes that would be expected if the dog was truly dysplastic. Most dogs with this grade (over 50%) show no change in hip conformation over time and receive a normal hip rating; usually a fair hip phenotype.

Mild


Mild Canine Hip Dysplasia (Figure 5): there is significant subluxation present where the ball is partially out of the socket causing an incongruent increased joint space. The socket is usually shallow only partially covering the ball. There are usually no arthritic changes present with this classification and if the dog is young (24 to 30 months of age), there is an option to resubmit an radiograph when the dog is older so it can be reevaluated a second time. Most dogs will remain dysplastic showing progression of the disease with early arthritic changes. Since HD is a chronic, progressive disease, the older the dog, the more accurate the diagnosis of HD (or lack of HD).


 

Moderate


Moderate Canine Hip Dysplasia: there is significant subluxation present where the ball is barely seated into a shallow socket causing joint incongruency. There are secondary arthritic bone changes usually along the femoral neck and head (termed remodeling), acetabular rim changes (termed osteophytes or bone spurs) and various degrees of trabecular bone pattern changes called sclerosis. Once arthritis is reported, there is only continued progression of arthritis over time.

Severe


Severe HD (Figure 6): assigned where radiographic evidence of marked dysplasia exists. There is significant subluxation present where the ball is partly or completely out of a shallow socket. Like moderate HD, there are also large amounts of secondary arthritic bone changes along the femoral neck and head, acetabular rim changes and large amounts of abnormal bone pattern changes.


Other Hip Dysplasia Registries—An Approximation

The Lower the score the better the hips

OFA

FCI (European)

BVA (UK/Australia)

SV (Germany)

E
A-1
0-4 (no > 3/hip)
Normal
G
A-2
5-10 (no > 6/hip)
Normal
F
B-1
11-18
Normal
B
B-2
19-25
Fast Normal
M
C
26-35
Noch Zugelassen
Mod
D
36-50
Mittlere
S
E
51-106
Schwere

Elbow displasia

Elbow displasia or ED is the term used to describe arthritis or DJD of the elbow, causd by growth abnormalities or incongruence of the elbow joint. Bad elbows frequently result in young dogs having to euthanized as diseased elbows are less easy to treat than bad hips and very painful. Moreover, research has shown that ED is highly heritable. If a dog has ED, a significant proportion of its offspring are also likely to have ED.

Elbows are graded 0-3, with O being clear, 1 mild ED , 2 moderate ED and 3 severe ED. Please see here for more information on ED and elbow scoring. A comprehensive discussion of ED can be found here.

All breeding dogs should have had their elbows x-rayed and submitted to a recognised grading scheme. In the UK, this is the BVA (NB there is a discount for scoring hips and elbows at the same time).

Some older dogs will not have been graded but should have a certificate from a veterinarian stating that the elbows have been x-rayed at 12 moths or older and found to be clear.

It is probably safest to assume that dogs which have only had their x-rays checked by a vet rather than officially graded may be 1:1 as a vet may not pick up the slight chnges which constitute mild ED.

The BVA recommend only breeding from dogs with 0:0 or 1:1 elbows.

British mean score below click to enlarge

Ideal scores would be below the scores stated below

Labradoodle 14

Labrador 15

Miniature Poodle 14

 

Pra Eyes

 The OptiGen prcd-PRA test is a DNA-based test that helps you avoid one form of Progressive Retinal Atrophy (PRA). PRA refers to a group of diseases that cause the retina of the eye to degenerate slowly over time. The result is declining vision and eventual blindness. “prcd” stands for “progressive rod-cone degeneration”

PRA Disease

The genetic disorder, prcd-PRA , causes cells in the retina at the back of the eye to degenerate and die, even though the cells seem to  develop normally early in life. The “rod” cells operate in low light levels and are the first to lose normal function. Night blindness results. Then the “cone” cells gradually lose their normal function in full light situations. Most affected dogs will eventually be blind. Typically, the clinical disease is recognized first in early adolescence or early adulthood. Since age at onset of disease varies among breeds, you should read specific information for your dog. Diagnosis of retinal disease can be difficult. Conditions that seem to be prcd-PRA might instead be another disease and might not be inherited. OptiGen’s genetic test assists in making the diagnosis. It’s important to remember that not all retinal disease is PRA and not all PRA is the prcd form of PRA. Annual eye exams by a veterinary ophthalmologist will build a history of eye health that will help to diagnose disease.

Unfortunately, at this time there is no treatment or cure for PRA. If your dog is affected, you may find it helpful to read about other owners’ experiences living with blind dogs.

Inheritance

Prcd-PRA is inherited as a recessive trait. This means a disease gene must be inherited from each parent in order to cause disease in an offspring. Parents were either “carrier” or affected. A carrier has one disease gene and one normal gene, and is termed “heterozygous” for the disease. A normal dog has no disease gene and is termed “homozygous normal” – both copies of the gene are the same. And a dog with two disease genes is termed “homozygous affected” – both copies of the gene are abnormal.

It’s been proven that all breeds being tested for prcd-PRA have the same disease caused by the same mutated gene. This is so, even though the disease might develop at different ages or with differing severity from one breed to another.

Although prcd-PRA is inherited, it can be avoided in future generations by testing dogs before breeding. Identification of dogs that do not carry disease genes is the key. These "clear" dogs can be bred to any mate - even to a prcd-affected dog which may be a desirable breeding prospect for other reasons. The chance of producing affected pups from such breedings depends on the certainty of test results. Again, you’ll find the specific information on certainty of test results for your dog by linking to breed specific information

The Genetic Test

The OptiGen prcd test is done on a small sample of blood from the dog. The test analyzes the specific DNA mutation causing prcd-PRA. The OptiGen test detects the mutant, abnormal gene copy and the normal gene copy. The result of the test is a genotype and allows separation of dogs into three groups: Normal/Clear (homozygous normal), Carrier (heterozygous) and Affected (homozygous mutant).

Possible results using the OptiGen prcd test
Genotype Risk Group Significance For Breeding Risk of prcd Disease
Homozygous Normal Normal/Clear Can be bred to any dog, extremely
low risk of producing affecteds
Extremely low
Heterozygous Carrier Should be bred only to Normal/
Clear to remove risk of producing
affecteds
Extremely low
Homozygous Mutant Affected Should be bred only to Normal/
Clear to remove risk of producing
affecteds
Very high

 

 

 

 

 

 

 

 

 

  

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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